A schematic of a method of using a representative compound embodiment.
Lead inventor: Michael Pluth
Co-inventors: Matt Cerda, Michael Pluth, Yu Zhao
Licensing contact: Christine Gramer

1. Technology Overview

The invention focuses on thiol-triggered sulfenyl thiocarbonates and sulfenyl thiocarbamates that release carbonyl sulfide (COS) and hydrogen sulfide (H2S) in the presence of biologically relevant thiols. These compounds offer a concomitant fluorescence response, providing optical indication of COS and H2S release. The technology is currently in the development stage, with promising cross-industry applications in biological detection, imaging, and targeted drug delivery.

2. Key Features and Benefits

  • Fluorescence response: Provides optical indication of COS/H2S release.
  • Diversifiable releasing group: Enables conjugation to various fluorophores and drug molecules.
  • Versatility: Applicable to various industries, including biotechnology and pharmaceuticals.
  • Scalability: Synthesis processes can be scaled for larger quantities.
  • Targeted applications: Ideal for biological detection, imaging, and drug delivery systems.

3. Applications and Market Focus

  • Biological detection: Use in detecting and imaging biological processes involving COS/H2S.
  • Drug delivery: Integration into targeted drug delivery systems.
  • Biotechnology: Development of novel biological detection and imaging methods.
  • Pharmaceutical industry: Synthesis of complex organic molecules for various applications.
  • Chemical industry: Use in advanced synthesis techniques and equipment.

4. Commercial Advantages

  • Strategic benefits: Provides reliable and scalable COS/H2S releasing compounds for various applications.
  • Implementation advantages: Facilitates integration into existing biological detection and imaging systems.
  • Market positioning: Positions technology as a key enabler for advanced biological detection and drug delivery systems.
  • Competitive advantages: Offers fluorescence response and diversifiable releasing group compared to existing methods.

5. Partnership Opportunities

  • Ideal licensing partners: Biotechnology firms, pharmaceutical companies, chemical industry leaders.
  • Cross-sector partnership benefits: Collaboration opportunities across biotechnology and pharmaceutical industries.
  • Diverse market opportunities: Potential for global market expansion in regions with strong biotechnology and pharmaceutical industries.
  • Collaborative development: Opportunities for joint development of hybrid devices and custom synthesis services.
Patent filing: US20210214368A1